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Furthermore, combinations of trastuzumab and drugs targeting the downstream pathway are described. No other anti HER2 biological agents showed better efficacy than pertuzumab and trastuzumab in first-line therapy. Recommendations on disease management for patients with advanced human epidermal growth factor receptor 2—Positive breast cancer and brain metastases: Hucow training for milking. Horny guards fuck hot schoolgirl's cunt with toys. Seductive young babe sex with horny old man Teen. Therefore, T-DM1 through this mechanism, leads to a double antitumor effect, an anti-HER2 effect mediated by the trastuzumab activity and a selective transport of a powerful antimitotic agent DM1 to the intracytoplasmic area.
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