This may also have implications for pregnancy-associated breast cancer as well as malignancies that develop in parous aging women. Generate a file for use with external citation management software. Interrupted reprogramming allowed controlled expansion yet preservation of lineage commitment. In addition, culture conditions affect lineage restriction as well as progenitor activity in vitro . This is because both transcription factors are also regulated by the pituitary hormone prolactin, which is critical for alveologenesis during pregnancy and differentiation during lactation [69, 70].
ErbB receptor regulation by dexamethasone in mouse type II epithelial cells
In mice, progesterone signaling through PR has been shown to be necessary during puberty and over the course of subsequent estrous cycles for ductal branching and for full alveolar development during pregnancy. The underlying biological reason for the difference in PR expression patterns between mice and humans is not clear. Through the use of multiple assays to detect progenitor activity, such as growth in matrix and treatment with combinations of hormones or injection into pregnant recipients, specific progenitor populations within the luminal lineage may be identified. They become more flattened and then shed. To put it another way, enterocytes are born at the bottom of the crypts, pass through childhood migrating up the walls of the crypts, then settle down briefly to enjoy an absorptive adulthood on the villi.
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The authors have declared that no competing interests exist. In addition to serovar L 2 , we tested the ability of other serovars and biovars of C. Aire, an important transcriptional regulator expressed in mature medullary thymic epithelial cells, was not detectable in TSCs but was highly expressed in the previously reported mature mTEC cell line Although a role for progesterone in stem cell maintenance in the adult gland has been identified , the direct effect of estrogen on adult stem cells has not been characterized. Keratin 14 K14 is only observed on mTECs. Chemokine secretion of human cells in response to Toxoplasma gondii infection. Although there is the absence of an adequacy decision from the European Commission to those countries and the region listed above, our company ensures to managepersonal data in an adequate way.
Optimal strategies to decrease the incidence of BPD in pre-term infants would involve the induction of surfactant synthesis without inhibition of alveolar development. Modulation of surfactant protein D expression by glucocorticoids in fetal rat lung. The effect of chloramphenicol is likely attributed to inhibition of chlamydia protein synthesis 25 because penicillin, which blocks reticulate body differentiation to EB 26 , only partly affected the IL response Fig. In aggregate, these data indicate that activation of caspase-1 is essential for chlamydia induction of IL secretion. The foregoing studies showed effects of dexamethasone and NRG on erbB receptor protein content. Cycloheximide, which is a eukaryotic but not prokaryotic protein synthesis inhibitor, had no affect on mature IL production after chlamydia infection Fig.